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Before the introduction of stabilized Acemannan in 1994 attempts were being made by scientists as early as the end of World War 2 to address beta radiation burns, which are some of the most painful burns. Literature was accessed from the Atomic Energy Commission that said they had employed fresh aloe vera gel to treat burns after the atomic bomb was dropped in 1945. This looked like a solution. However, it soon became obvious that Acemannan (contained in the inner leaf gel in the aloe vera plant), and is the reason for the healing dynamic, that it denatured within 24 hours and it would be many years before Acemannan would be stabilized and brought to market.
I’ve covered Acemannan and chemotherapy previously, but this is a look at two studies about Acemannan and radiation. So, let’s put the slides up and get started.
The radiation we are talking about is the radiation used in cancer therapy. These are gamma rays and this is also called radiotherapy. It is invasive and can produce undesirable side-effect impacts. Radiation therapy includes the objective to target cancer cells, but can also negatively affect nearby healthy tissue. This is common knowledge and is well documented.
So, with our focus on gamma rays released via radiation therapy, we are going to take a look at two studies where lab animals were subjected to gamma rays, to radiation therapy.
Because these studies are complex, I take the liberty to provide a paraphrase and bring meaning to the big scientific lingo. I’ll put actual excerpts on the screen from the studies, and you can pause the video if you would like to read them yourself. And the paraphrase and summary will follow.
This first study, one from 2018 is entitled: Role of acemannan O-acetyl group in murine radioprotection
Native or over-acetylated or deacetylated acemannan pre-treatment to mice has shown to reduce the γ-radiation-induced oxidative damage, and hematopoietic injuries by free radical scavenging and microphage activation (secretes pro-hematopoietic factors through TLR-4) respectively.
Paraphrased summary: Acemannan used as a pre-treatment in mice exposed to gamma rays reduced oxidative damage caused by those gamma rays. Acemannan also reduced injuries to stem cell processes which play critical roles in the bone marrow resulting in oxygen transport (red blood cells), immune defense (white blood cells), and blood clotting (platelets). Acemannan also contributed to the elimination of free-radicals and the activation of the macrophage, which plays a crucial role in the immune system.
To summarize further:
- Acemannan reduced oxidative damage caused by gamma rays
- Acemannan also reduced injuries to stem cell processes
- Acemannan contributed to the elimination of free-radicals and activation of the macrophage
Now let me access a second study: This one is from 2015, entitled: Immunomodulatory potential of acemannan (polysaccharide from Aloe vera) against radiation induced mortality in Swiss albino mice
From Intro: Exogenous treatment with cytokines is reported to have radioprotective effects by inducing the proliferation and recovery of hematopoietic cells resulting in decreased mortality after radiation exposure (Neta, 1988). The recovery of the radiation depleted cells has been reported to take place via autocrine or paracrine mode of action in immune competent mouse (Shukla & Gupta, 2012). However, high toxicity associated with these cytokines has restrained the medical fraternity, to use them in practice (Goel et al., 2007). Therefore, development of non-toxic immunostimulatory agents is important for the mitigation of radiation injuries.
Paraphrased summary: The damage of radiation exposure that is obvious and predictable is best addressed NOT by agents or medications that are high in toxicity, but by non-toxic agents that stimulate the immune system, which are important for the mitigation (alleviation, improvement) of radiation injuries.
To summarize further
- The damage of radiation exposure
- is best addressed NOT by medications high in toxicity
- but by non-toxic agents that stimulate the immune system for the improvement of radiation injuries
Hmmm. I wonder what agent would qualify as non-toxic that could also stimulate the immune system?
From Intro: In previous studies, polysaccharides extracted from various biological sources such as soybean, Ocimum sanctum, ginseng, mulberry leaves, wolfberry, mushroom and fungi have been reported to protect against the radiation-induced damage by regeneration of the hematopoietic stem cells and thus strengthening the immune system and preventing against the immune depression induced by radiation (Kim et al., 2009; Liu, Guo, Zhang, Qin, & Han, 2012; Yao et al., 2011). However, so far discovery of an ideal radioprotector/mitigator has remained elusive.
Paraphrased summary: Previous studies where polysaccharides have been extracted from various botanical sources have been reported to protect against radiation damage by regenerating stem cells, thus strengthening the immune system and preventing against immune depression that is induced by radiation. However, so far discovery of an ideal agent has remained elusive. Has it?
- Polysaccharides from botanical sources
- protect against radiation damage by regenerating stem cells
- strengthening the immune system
- preventing against immune depression induced by radiation
- so far, an ideal agent has remained elusive
The study is implying that Acemannan might just be that ideal agent.
From Intro: An interesting aspect of acemannan is that, the anticancer activity is not due to cytotoxicity to the cancer cells; instead it is mediated via immunomodulation.
Paraphrased summary: Acemannan has no anticancer activity whatsoever. If you place Acemannan and cancer cells (any aberrant cells) in the same petri dish Acemannan will not, cannot, kill the cancer cells. The only way that Acemannan provides any contribution to intervention or mediation is because of its natural ability to modulate the immune system. The immune system then does what the immune system is designed to do, and fights unwelcomed diseased cells. Acemannan becomes a welcomed dynamic to the innate intelligence of the immune system only to further optimize the activity of that immune system.
To summarize further:
- Acemannan has no anticancer activity
- Acemannan provides intervention or mediation because of its natural ability to modulate the immune system
- Acemannan becomes a welcomed dynamic to the innate intelligence of the immune system
- To optimize that immune system
From Discussion: In conclusion, we have demonstrated that acemannan derived from widely used aloe vera gel exerted its radioprotective effects in the pre- and post-irradiation treatment in mice. The acemannan treatment resulted in the increase in the survival by protecting against radiation damage by upregulating the immune system and inducing proliferation of the hematopoietic cells in WBI mice. Further, acemannan has been shown to protect the animals in the post-irradiation studies and is non-toxic at high doses, hence can be exploited as a radiation mitigating agent in case of unplanned exposures.
Paraphrased summary: In conclusion, Acemannan exerted its radioprotective effects in the pre- and post-radiation exposure to mice. The Acemannan treatment resulted in the increase in survival by protecting against radiation damage by upregulating the immune system and inducing proliferation of the blood-producing stem cells (which is what the 2015 study concluded). Further, Acemannan has been shown to protect the animals in the post-irradiation studies and is non-toxic at high doses, hence Acemannan can be exploited as a radiation mitigating agent especially in case of unplanned exposures.
- Acemannan exerted its radioprotective effects
- Acemannan resulted in the increase in survival by protecting against radiation damage
- By upregulating the immune system and inducing proliferation of the blood-producing stem cells
- Acemannan is non-toxic at high doses
- Acemannan can be exploited as a radiation mitigating agent. This isn’t a sponsor with a vested interest to get a scientist to say this. This is the conclusion of a scientific study.
This is just another couple of studies that points to the effectiveness of Acemannan (especially in the context of radiation exposure) and why it continues to be a compelling idea for human consumption. This discovery is certainly no longer elusive. Plus, we build from a Social Business 3.0 platform that generates Acemannan nutrition for vulnerable children when consumers make the decision to impact their own lives by acquiring our products. Simply stated: We tap the market to save lives. Access the link I provide below to know more.
I hope you will always be careful to maintain good works to meet urgent needs and become heroes to your generation.
The statements and ingredients referred to throughout this document have not been evaluated by the FDA.
They are not intended to diagnose, treat, cure or prevent any disease or condition.
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