We are going to take a look in this video at an independent scientific study that used the actual stabilized Acemannan powder, contained in the capsules that our Social Business team markets to the public, and which is the core of the nutrition we send to malnourished children. This study will employ this stabilized Acemannan powder and send it through five different assessments. So, let’s get started
This study is called: “Evaluation of Immunological Activities of an Organic Freeze-Dried Inner Leaf Aloe vera L. Powder.” This study addressed Phagocytosis, Antibody Creation, Immune Signaling, and Superoxide and Nitrite Oxide production. I will soon provide definitions and elaboration as we move forward.
The author of this study engaged both in vivo (inside a living organism) and in vitro (test tube) experiment models. The in vivo was the use of mice, which were subjected to various injections. Some were injected with Acemannan, and others with PBS. PBS is Phosphate-Buffered Saline solution. This is a common laboratory solution and used as the “negative control.” What negative control means is that it’s not supposed to do anything—it doesn’t kill cells or stimulate cells, and it doesn’t contain any active ingredients. Because this is the case it becomes the “yardstick” of measurement against which everything else is compared—and therefore is referred to as the negative control. Negative meaning it brings NO impact to the experiment.
And I’ll introduce the in vitro or test-tube-like environment shortly
The Acemannan powder used in this study, that myself and a team of consumers are familiar with in capsule form, was obtained directly from the company owned by Dr. Santiago Rodriguez. The registered trademark he uses to identify the product is BiAloe®. You will see that term on the graphs I will display shortly. When you see it you can know that that is Acemannan. This is referenced in both this study and in Dr. Rodriguez’ website. Dr. Rodriguez is who has developed the processing of this highly efficacious Acemannan, which (in the words of this study) “claims to have the highest immunomodulatory Acemannan . . . fraction of the commercially available aloes.” And, by the way, unless something has changed since the recording of this video, that claim remains and is the same Acemmanan we market using our Social Business 3.0 model. It is also the same Acemannan we send to medically vulnerable children around the world.
You’ve heard me talk about Dr. Santiago Rodriguez in other videos including this one at this link.
Phagocytosis is kind of like your body’s version of the earliest computer games, where an animated figure roams the computer screen and gobbles up all the little dots in the maze. In similar manner, certain immune cells in your body roam around and “gobble up” harmful things—like bacteria, viruses, or dead cells. Phagocytosis is the process by which immune cells “eat” unwelcomed particles. Phago means to eat. Cyto means cell. Osis means process.
Put it all together:
Phagocytosis = “the process of cell eating.”
This eating process involves neutrophils, a type of white blood cell. The researcher in this study provided something for the neutrophils to eat that could be measured in the form of tiny particles called HEMA particles. These are very tiny synthetic beads that act like fake invaders.
How tiny? A HEMA particle is typically between 1 to 3 micrometers (µm) in diameter. A micrometer is 1 millioneth of a meter or 0.000001 meter. To get a perspective, a red blood cell is about 6 to 8 µm wide. A human hair is about 70–100 µm thick. So HEMA particles are about 30 to 100 times smaller than the width of a hair. HEMA particles are small enough to be engulfed by the immune cells like neutrophils during phagocytosis, but large enough to be seen under a microscope after staining for evaluation.
After a test tube effort to mix the HEMA particles with blood samples and properly incubate them at body temperature for one hour, they were evaluated under a microscope. Each test was done 3 times and they looked at 200 cells each time to assure accuracy.
The graph lets us see results. The mice given the PBS (the Phosphate-Buffered Saline solution), indicated by the purple bars expressed evidence that phagocytosis did indeed take place in the natural order of things. However, where Acemannan was employed (indicated by the red bars) shows increased phagocytosis was the result at the various doses of 25 micrograms; 50 micrograms; and 100 micrograms of Acemannan.
This also shows that not only was there an uptick in phagocytosis but the more Acemannan given, the better the immune activity, at least within this tested range. Scientists call this kind of pattern a dose-dependent effect—which means the response improves as the dose increases. And, as you may remember, we have seen this does-dependent effect before in other experiments with Acemannan found at these three links:
The next experiment was in vivo (inside a living organism) to see if Acemannan could make an effect on Antibody Production in mice.
Antibodies are proteins your immune system creates to fight off specific invaders.
The researchers used ovalbumin (a protein from egg whites) to trigger an immune response, indicated by the purple bars.
And the red bars demonstrate that the lowest doses of Acemannan given to the mice (25 and 50 micrograms), did not show much improvement in antibody production. But mice given the highest dose (100 micrograms) made a lot more antibodies. This means Acemannan helped the immune system get stronger, but only at the higher dose.
One question that might come up at this point in terms of thinking in higher doses to get results, is if there are any side effects or toxicity issues with the use of large doses of Acemannan. In referencing a different study titled “Toxicologic evaluation of injectable Acemannan in the mouse, rat and dog” the author of this study said, “Furthermore, solid data on rats, mice and dogs showed no significant signs of intoxication or death even after massive doses.” It becomes more and more obvious as consumers and interested parties get acquainted with Acemannan that it simply has no toxic impact.
This idea was included in this video at this link:
Furthermore, Acemannan has been shown to protect the animals in the post-irradiation studies and is non-toxic at high doses, hence Acemannan can be exploited as a radiation mitigating agent.”
The next part of this study focused on Immune Signaling (in vivo). IL-2, otherwise known as Interleukin-2, is a protein made by immune cells (specifically spleen cells) that helps other immune cells grow and respond to infection.
Normally, cells that haven’t been activated make very little IL-2—only about 20 picograms, which is an incredibly small amount and is indicated here by the purple bars. But when the spleen cells from the mice that were given the Acemannan were examined and measured, they made much more IL-2. This shows that the Acemannan clearly helped switch on immune communication, indicated significantly by the higher measurements. Dose-dependency is here again noted.
Before I make transition to the next point let me add more perspective to the question: just how much is 100 micrograms of Acemannan exactly?
If you convert it to
Ounces = 100 micrograms of Acemannan Powder is 0.0000035 oz
Teaspoons = approx. 1/10,000th of a teaspoon (so tiny its invisible to the naked eye)
A single grain of table salt weighs about 60,000 µg — meaning 100 µg of Acemannan powder is about 1/600th of a single grain of salt.
To say the least, that amount of Acemannan is extremely small.
A mouse that weighs 25-30 grams is given 100 micrograms of Acemannan is roughly equivalent to 400 milligrams for a 200-pound person.
Is this realistic? Yes, two 200mg capsules a day would be the equivalent based on body weight for a 200-pound adult. So this falls within a realistic human dose range.
Then next, researchers folded into the in vivo model, an in vitro or test-tube-like environment where they employed lab-grown human cells known as HL-60 cells. These are a type of white blood cells used in science to study blood cell behavior.
The next emphasis was the utilization of Acemannan in an effort to supercharge defensive molecules by creating superoxide production.
Superoxide is a chemical that immune cells release to attack harmful invaders. Scientists tested for how much superoxide was being produced. In this experiment they used both normal immune cells from mice (in vivo) and a lab-grown version of HL-60 (in vitro), which are the human cells I just mentioned.
In this case, the Acemannan caused the immune cells to release a lot more superoxide, showing that the Acemannan helped the immune system become more aggressive toward threats when needed. The graph indicates that Acemannan was highly active with a strong dose dependency, meaning, to repeat, the more Acemannan the higher the results.
Nitrite oxide
Finally, after giving Acemannan, they measured how much Nitrite Oxide was made, another molecule used by the immune system to fight off infection. The chemical formula for Nitrite Oxide is NO2 – The negative charge makes a big difference in chemisty. “So—when you write home to your mother about your research, don’t forget the minus sign on NO₂⁻. Otherwise, she’ll think you’re working with nitrogen dioxide, not nitrite oxide. One supports cellular signaling in the immune system the other’s a toxic gas. Big difference. She might worry.”
Just like the superoxide, the immune cells made much more nitrite oxide, and again, it pointed to dose-dependency, where the higher the dose, the stronger the effect, but without toxicity.
This Acemannan helped wake up the immune system in multiple ways:
It helped white blood cells eat invaders more effectively via improved Phagocytosis
It increased antibody production (at high doses).
It made cells communicate better by producing more IL-2.
It boosted the production of chemical weapons like superoxide and nitrite oxide.
And dose-dependency was common where higher doses made the immune system work even better.
In the words of the study, it concluded with,
“Data presented in this study clearly demonstrated that (Acemannan powder) is a biologically active material, particularly in doses of 50 and 100 micrograms. This material affects both branches of the immune reaction, i.e. the cellular and humoral immunity.”
Cellular Immunity is how your body defends itself at a cellular level
Humoral immunity is how your body defends itself at a body fluids level. “Humor” is the Latin word for fluid.
I hope you will always be careful to maintain good works to meet urgent needs and become heroes to your generation.
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