Macrophage Activation: The Hidden Secret of Aloe Vera’s Most Powerful Compound
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Acemannan is considered the most researched natural molecule in history. Over 700 peer-reviewed studies backed by 130 worldwide patents. And 30 years of testimonials. By 1994 Carrington Laboratories had spent $100 million dollars in their discovery and stabilization of Acemannan.
I am personally challenged to be patient with the process of marinating this incredible information into people I know and love. What I find is that many people still treat this nutritional technology like it’s just another bottle on the shelf at the health food store (though, listen closely, Acemannan cannot be found on a shelf at the health food store).
But it is safe to say that there are probably 240 million people in the United States alone who could put Acemannan to good use right this second, because of immunodeficiency and related health problems.
And another group that could use its impact are the seven million children who die yearly because of complications from malnutrition. And who are a vital part of our mission. They depend on our success. So, as usual let’s dig deeper and reach wider.
Among all the data I can access I am going to narrow down to a single question: Of all the great things that Acemannan contributes, what is its absolute most desired effect?”
If you’re like me and you are convinced (and I hope you are) that your immune system is the best thing that has happened to you on a physiological level and has kept you alive this long, despite how we have ignored it; abused it, or taken it for granted, then the most desired effect you and I hope for is macrophage activation. This is what the largest body of research reveals concerning Acemannan. And, if your immune system is the best thing that has happened to you then Acemannan is the best thing that can happen to your immune system.
At its core, the immune system isn’t something that necessarily needs fixing—But it is a dynamic, highly intelligent system constantly adapting to stress, environment, nutrition, and age. Acemannan’s real opportunity isn’t rescue, but modulation—proactively modulating the immune system so it naturally functions at its best. So, Acemannan doesn’t replace the immune system, it undergirds and lends resilience to its overall performance in a biological environment that continually places new demands on it.
But let’s get back to this idea of macrophage. What is a macrophage?
The macrophage (which means big eater) are the large white blood cells made in the bone marrow. They regulate the immunomodulating functions of the immune system. They are vital. They facilitate wound healing and infection control and serve to detect and eliminate foreign antigens or microorganisms that come into the gut. 70 to 80% of all macrophages in your body and in your immune system are housed in the gut. That is where the front line of defense takes place. The gut is the epicenter of your immune system
Before I go on, I need to insert this: Acemannan was discovered in 1985 and was taken to market 1994. When it comes to measuring Acemannan and breaking it down into its quantifiable parts, the chemical structures therein are measured in a unit of measurement called a Dalton. I bring this up to create some perspective here. Acemannan molecules can go from a thousand Daltons of molecular weight to a few million Daltons of molecular weight. So, obviously that’s a very wide range of structures.
These structures are divided up into three sizes that have different effects on human physiology. They are short, medium, and long chains and they all make a nutritional contribution. In simple terms the short chains of Acemannan are bioavailable, they get into the bloodstream. The medium chains activate the immune system, and the long chains serve as prebiotics (mostly fiber that feeds friendly bacteria in your gut). This also creates an environment for conversion to short chain fatty acids with their many beneficial effects, including a significant contribution to colon health.
In 2005 there were nine scientists in Korea who also were asking the same question: “What is the most desired effect of Acemannan?” However, they went a little further with the question, like good scientists are inclined to do. And they asked if they could identify the optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity? In other words, in smarter than a fifth grader style, which sizes of these Acemannans actually did the best at turning on the immune system. They determined that that would be a good thing to know IF your objective was to turn on the immune system, which is the most desired effect. Have I said that already?
Here is what they found. I’ll quote directly from the research and on the next slide I’ll provide an expansion of scientific definitions so you can pause the video and if you want to study it further:
The study concluded: “We found that polysaccharides between 400 and 5 KDa (400,000 and 5,000 Daltons) exhibit the most potent macrophage-activating activity as determined by increased cytokine production (which is the release of signals to help immune cells communicate), nitric oxide release (which helps to regulate immune defense), expression of surface molecules (to communicate with other cells), and phagocytic activity (where immune cells engulf and eliminate harmful invaders). In accordance with the in vitro activity, polysaccharides (a reference to Acemannan) between 400 and 5 KDa (400,000 and 5,000 Daltons) also exhibited the most potent antitumor activity in vivo.” In vivo means “inside a living organism.” That sounds like good news.
Here’s the slide I mentioned, if you want to pause and read: We found that Acemannan between 400,000 and 5,000 Daltons exhibit the most potent macrophage-activating activity as determined by increased cytokine production, Cytokines act as mediators of communication between cells, regulating immune responses, inflammation, hematopoiesis (the formation of blood cells), and other biological processes) nitric oxide release, Nitric Oxide acts as a signaling molecule in numerous biological systems, including the cardiovascular, nervous, and immune systems. expression of surface molecules, play key roles in cell signaling, communication, and interactions with other cells or the extracellular environment. and phagocytic activity Phagocytic activity refers to the ability of certain cells to engulf and digest foreign particles, such as bacteria, viruses, dead cells, and cellular debris. Phagocytosis is a crucial component of the immune response, serving as a primary mechanism for eliminating pathogens and other harmful substances from the body.. In accordance with the in vitro activity refers to experiments that are conducted outside of a living organism, typically in a controlled laboratory setting., polysaccharides between 400 and 5 KDa also exhibited the most potent antitumor activity refers to the ability of the immune system to recognize, target, and eliminate cancer cells in vivo. refers to experiments or observations that are conducted within a living organism.
Acemannan between 5,000 and 400,000 Daltons exhibits the most macrophage activation activity. They found the sweet spot. So, polysaccharides below 5K Daltons, or above 400K Daltons showed minimal immune activating results, though they did make other significant nutritional contributions. There’s nothing about Acemannan that is wasted. So, now, for the first time in history, though the first generation of Acemannan had been on the market for eleven years at that point and was gaining a positive reputation, scientists knew exactly which molecular weights of Acemannan were achieving the desired effect. Now that might not seem too important to you and me, but it got the attention of a certain
Dr. Santiago Rodriguez, (sorry, but yes I have a picture of Dr. Rodriguez and myself) a PhD organic chemist, who, incidentally, developed the first generation of Acemannan and that changed lives all over the world. He was the one who designed the processing for the stabilization of Acemannan. Dr. Rodriguez looked at this new scientific discovery from Korea with a great amount of interest and tapped its insight.
But first, he determined to take the first generation of Acemannan and break it down into its various molecular weights (you know the Dalton thing) to see what it looked like. And this is what he found. Of course, there are other ingredients that exist in the solids of aloe vera, not just Acemannan. This would include trace elements, peptides, etc. Dr Rodriguez revealed then what he found in that first generation.
For every gram, 10.2% was Acemannan. He then researched, based on the new science, of that 10%, how much falls into the category of immune activation. 40% of that 10% or 4% of the total composition activated macrophages. And then he determined how much is bioavailable that absorbs into the bloodstream. A little less than 2%.
So, this is the basic, first generation of Acemannan. However, as successful and as efficacious as this first version of Acemannan has been he wondered if he could improve on that composition. So, he went to work . . .
He was able to double the amount of Acemannan per gram, to almost 20%. In terms of the immune activating fractions (and remember this is the most desired effect) it went from 4% to 18% of each gram of composition. Four and one-half times increase in immune activation. And look at the smallest chains, which are absorbable into the bloodstream: it went from 2% to almost 10%, more than five times increase in bioavailable Acemannan.
Dr. Rodriguez’s intention was to license this technology to some company who could take it to the world. That is when MannaRelief sat down with him and explained their Social Business 3.0 initiative, which included taking it to the global market but with a commitment of matching the nutrition and sending it to the world’s most vulnerable children to save lives. Dr. Rodriguez loved the idea and donated the exclusive licensure rights of this technology to MannaRelief and the Hope Movement. To say that he is a friend of the malnourished of the world is an understatement.
One day my curiosity got the best of me, and I made inquiry into what a license of this kind of technology might be worth. In 1994 it was worth $2,000,000, so it’s likely to be worth even more 30 years later, especially in consideration of its increased efficacy and market success during that time. This second generation, this advanced technology of nature’s most efficacious immune supporting molecule is exclusively distributed on the Social Business 3.0 platform, and you should know more. Click on the links below. Access HopeQuestGlobal.com
Meanwhile, this is Tony McWilliams I hope you will always be careful to maintain good works to meet urgent needs and become heroes to your generation.
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